Description of Duromine

Duromine is a weight loss drug. Duromine is produced in the form of firm gelatin capsules of grey-green color. Each Duromine capsule contains Phentermine active substance.

The available dosage of the drug containing 15 and 30 mg of Phentermine active substance are Duromine 15 and Duromine 30 respectively. Duromine belongs to Controlled Drug C5 group.

As excipients, each Duromine capsule contains lactose, liquid paraffin, octadecanoic acid, gelatin, titan dioxide and iron oxide black.

In addition to the mentioned ingredients, Duromine 15 capsules contain some food colorings, like Brilliant Blue (CI 42090) and iron oxide CI 77492, while Duromine 30 capsules contain iron oxide CI 77491 as food coloring.

Duromine capsules contain no gluten and no preservatives.

Capsules Use

Phentermine is used as an active ingredient in Duromine. Phentermine is a sympathomimetic amine and provides an appetite suppressant effect.

By acting on dopaminergic and noradrenergic systems, Phentermine provides the suppression of hunger effect. In other words, Duromine reduces the appetite in people who use Duromine. Instead, they feel a great burst of energy and strength.

Other than that, Phentermine can stimulate the NK-cells (lymphocytes) and affect the lipid metabolism.

Duromine Pharmacokinetics

By itself, Phentermine active ingredient is almost insoluble. It does not show any pronounced pharmacological properties until it reacts with gastro-intestinal juice.

As a result of chemical reaction between the gastro-intestinal juice and Duromine, a gradual release of the active substance Phentermine begins, which later is absorbed in the gastrointestinal tract of a patient.

The release time of Phentermine may last 10 to 14 hours, and when it splits, a person’s hunger is blunted.

Phentermine, found in Duromine capsules is easily excreted from the gastrointestinal tract. Thus, about 80% of Duromine (Phentermine) dosage is excreted in the urine unchanged. The rest of it is metabolized in the liver.

The half-life of Phentermine is approximately 25 hours.

Indications

Duromine is prescribed as a short-term medicine for a complex approach in anti-obesity therapy. Along with physical exercises and a balanced diet, Duromine provides anorexigenic effect on the human body.

First of all, when doctor prescribes Duromine, he should consider the body mass index (BMI) of a patient.

Duromine is recommended for people, whose BMI equals:

  • 30 and more
  • 27 to 29.9

Well, it is clear why people with BMI 30 are prescribed Duromine. But cases when doctors prescribe Duromine to patients, whose BMI ranges between 27 and 29 requires an explanation.

Let’s start with the fact that the body state when the BMI equals 27 is already considered as pre-obesity.

Not to mention if this state is accompanied by some other serious health disorders, then Duromine becomes a necessary measure for an overweight patient. Diseases considered as health-threatening states are as follows:

  • Sleep apnea (stop of breathing during sleep);
  • Insulin-resistant forms of diabetes mellitus;
  • Cardiovascular diseases (heart attack, stroke and coronary artery disease).

The inability to achieve at least 5% of weight loss during the first 12 weeks means that a patient should terminate the treatment using this drug.

However, the treatment itself can be longer than it was prescribed, if a patient loses some weight and if he or she is under a constant medical supervision during the whole treatment course.

Before a patient is prescribed Duromine, all the secondary causes of obesity must be eliminated.